Presenter Information

Emily R. Leung1, Nina A. Reger1, Ashley Blystone1, Ellen S. Gawalt1,2

1Department of Chemistry and Biochemistry, Duquesne University

2McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA

Abstract

Titanium metal is a commonly used implant material which can be colonized by bacteria. Biofilms are formed when bacteria colonizes, attaches to a surface, and immobilizes. Bacterial infections or biofilms are hard to treat once formed on the surface of a metal implant. Coating the material may minimize bacteria attachment. Self-assembled monolayers are comprised of molecules that contain both a head and tail group, and can be used to coat metal to prevent biofilm formation and bacteria growth. 12-mercaptododecylphosphonic acid self-assembled monolayers have a phosphonic acid head group and a thiol tail group. A solution of
12-mercaptododecylphosphonic acid in tetrahydrofuran was used to form self-assembled monolayers on the surface of titanium. Diffuse reflectance infrared Fourier transform spectroscopy was used to evaluate the attachment of the self-assembled monolayers. Alkyl-chain ordered self-assembled monolayers formed on the titanium surface, with the thiol tail group free at the interface for additional reactions. The monolayer attachment strength was further tested through acid, base, and tape tests.

School

Bayer School of Natural and Environmental Sciences

Advisor

Dr. Ellen S. Gawalt

Submission Type

Paper

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Modification of an Implant Material

Titanium metal is a commonly used implant material which can be colonized by bacteria. Biofilms are formed when bacteria colonizes, attaches to a surface, and immobilizes. Bacterial infections or biofilms are hard to treat once formed on the surface of a metal implant. Coating the material may minimize bacteria attachment. Self-assembled monolayers are comprised of molecules that contain both a head and tail group, and can be used to coat metal to prevent biofilm formation and bacteria growth. 12-mercaptododecylphosphonic acid self-assembled monolayers have a phosphonic acid head group and a thiol tail group. A solution of
12-mercaptododecylphosphonic acid in tetrahydrofuran was used to form self-assembled monolayers on the surface of titanium. Diffuse reflectance infrared Fourier transform spectroscopy was used to evaluate the attachment of the self-assembled monolayers. Alkyl-chain ordered self-assembled monolayers formed on the titanium surface, with the thiol tail group free at the interface for additional reactions. The monolayer attachment strength was further tested through acid, base, and tape tests.

 

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